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Ligand-Friendly Screen
自 2004 年以来，配体友好筛选 (LFS)4 一直是牛津结构基因组学联盟 (SGC) 的两个主要粗筛选之一； 据最新统计，它在 10 年中生产了 190 种新颖的结构。 LFS 在 Ng, J. T. et al, 20153 中进行了描述。由创建成功 BCS 屏幕的同一组在牛津的 SGC 开发，该团队于去年推出并基于由珍妮特纽曼在协作结晶中心创建的流行 PACT 屏幕4， CSIRO。
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Key Features:
- Identify more tight-binding ligands, as it contains no components that are likely to bind at protein-ligand interaction sites.
- Near physiological pH conditions ensure you are studying the active form of your protein.
- More hits for rarely-crystallising proteins. The semi-systematic format of the screen provides multiple trials of similar conditions – an important factor for difficult cases.
- Increased hit rate for ligand co-crystallisations – the semi-systematic format efficiently screens around related conditions when complex formation alters crystallisation conditions.
- In use at the SGC for more than 10 years, crystals grown in the screen conditions have resulted in 190 structures so far, including those of Haspin and CLK3 in recent publications.