XP Screens – Intelligent Crystal Screens-MiTeGen智能晶体筛选屏幕

XP Screens – Intelligent Crystal Screens-MiTeGen智能晶体筛选屏幕

上海金畔生物代理MiTeGen品牌蛋白结晶试剂耗材工具等,我们将竭诚为您服务,欢迎访问MiTeGen官网或者咨询我们获取更多相关MiTeGen品牌产品信息。XP Screens – Intelligent Crystal Screens

XP Screens – Intelligent Crystal Screens

XP Screens promote protein crystallization even for most challenging targets and improve diffraction quality of protein crystals. The XP Screens are TEW-optimized JBScreen Basics: 96 of the most prominent crystallization conditions complemented with TEW as “glue” for protein molecules.

XP 屏幕 – 智能水晶屏幕
即使对于最具挑战性的目标,XP Screens 也能促进蛋白质结晶,并提高蛋白质晶体的衍射质量。 XP Screens 是 TEW 优化的 JBScreen 基础:96 种最突出的结晶条件与 TEW 作为蛋白质分子的“胶水”相辅相成。

There are two variations of the XP Screens:

The XP Screen, SKU M-CS-350, is a convenient initial screen that has successfully induced protein crystallization with low TEW concentrations such as 1 mM. In some cases however, higher concentration of 5 or 10 mM TEW are needed.

The XP Up Screen, SKU M-CS-351, is an upgrade of the well-established XP Screen. It contains 96 of the most prominent screening solutions that are long-term stable in the presence of up to 10 mM TEW.

The Anderson-Evans Polyoxotungstate (TEW), SKU M-X-TEW-5, is a universal and flexible crystallization additive that is integrated the XP Screens. It was shown to improve crystal quality and resolution.

XP 屏幕有两种变体:

XP Screen,SKU M-CS-350,是一种方便的初始筛选,已成功诱导低 TEW 浓度(如 1 mM)的蛋白质结晶。 然而,在某些情况下,需要更高浓度的 5 或 10 mM TEW。

XP Up Screen SKU M-CS-351 是成熟的 XP Screen 的升级版。 它包含 96 种最突出的筛选解决方案,在高达 10 mM TEW 的情况下长期稳定。

Anderson-Evans 聚氧钨酸盐 (TEW),SKU M-X-TEW-5,是一种通用且灵活的结晶添加剂,与 XP Screens 集成。 它被证明可以提高晶体质量和分辨率。

Learn More About The XP Screens
XP Screens – Intelligent Crystal Screens SKU: M-CS-351 $830.00
XP Screens – Intelligent Crystal Screens SKU: M-CS-350 $442.00
XP Screens – Intelligent Crystal Screens SKU: M-X-TEW-5 $534.00

Categories: Crystallization Screening & Optimization, Crystallization Screens, New Products

Product Information

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  • Tech Notes

The Advantages of XP Screens include:

  • Convenient initial screening with up to 10 mM TEW
  • Improved crystal quality and resolution
  • Tight crystal contacts
  • New crystal forms (e.g to provide access to binding pockets)
  • Direct phasing

The Anderson-Evans Polyoxotungstate [TeW6 O24] 6- (TEW), SKU M-X-TEW-5,  is a universal and flexible crystallization additive that is integrated in the XP Screens. It was shown to improve crystal quality and resolution by:

  • Binding to the protein surface and forming tight crystal lattice contacts[3-7]
  • Acting as linker in various orientations and thereby creating either smaller
    (PDB: 4OUA) or larger (PDB: 4PHI) protein-protein distances[3,4]
  • Heterogeneous crystallization of two different protein forms in one single crystal
    (PDB: 4OUA)[4]
  • Inducing new crystal forms with access to the active site (PDB: 6ZDK, 6ZDL, 6ZFA)[5]
  • Covalently binding and structurally adapting to fit into protein molecules
    (PDB: 4Z12, 4Z13)[2]
Download XP Screens Technical Flyer
类别:结晶筛选和优化, 结晶筛, 新产品
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技术说明
XP Screens 的优点包括:使用高达 10 mM TEW 进行便捷的初始筛选
提高晶体质量和分辨率
紧密的水晶触点
新的晶体形式(例如提供对结合口袋的访问)
直接定相
Anderson-Evans 聚氧钨酸盐 [TeW6 O24] 6- (TEW),SKU M-X-TEW-5,是一种通用且灵活的结晶添加剂,可集成到 XP Screens 中。它被证明可以通过以下方式提高晶体质量和分辨率:与蛋白质表面结合并形成紧密的晶格接触[3-7]
充当各种方向的链接器,从而创建更小的
(PDB:4OUA)或更大(PDB:4PHI)蛋白质-蛋白质距离[3,4]
一种单晶中两种不同蛋白质形式的异质结晶
(PDB:4OUA)[4]
通过访问活性位点诱导新的晶体形式(PDB:6ZDK、6ZDL、6ZFA)[5]
共价结合并在结构上适应以适应蛋白质分子
(PDB: 4Z12, 4Z13)[2]