生物活性

纯度 & 产品资料

参考文献

生物活性

Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against?influenza virus?and multiple?coronaviruses, such as?SARS-CoV-2,?MERS-CoV,?SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].

体内研究
(In Vivo)

Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease[1].
Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice (intranasal infection with SARS-CoV)[1]

Dosage:

50, 150, 500 mg/kg

Administration:

Oral; every 12 hours for 3 days

Result:

Body weight loss is significantly diminished or prevented.

Clinical Trial

NCT Number

Sponsor

Condition

Start Date

Phase

NCT04392219

Ridgeback Biotherapeutics, LP

Coronavirus

April 10, 2020

Phase 1

NCT04939428

Merck Sharp & Dohme Corp.

Coronavirus Disease (COVID-19)

August 11, 2021

Phase 3

NCT04405739

Ridgeback Biotherapeutics, LP

SARS-CoV 2

June 16, 2020

Phase 2

分子量

329.31

Formula

C13H19N3O7

CAS 号

2492423-29-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder

-20°C

3 years

4°C

2 years

In solvent

-80°C

6 months

-20°C

1 month

溶解性数据

In Vitro:?

DMSO : 50 mg/mL?(151.83 mM;?Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM

3.0367 mL

15.1833 mL

30.3665 mL

5 mM

0.6073 mL

3.0367 mL

6.0733 mL

10 mM

0.3037 mL

1.5183 mL

3.0367 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

D、销售的所有产品均不得用于人类或动物之临床诊断或治疗，仅可用于工业或者科研等非医疗目的。