Recombinant enzyme prepared from insect cells infected with baculovirus containing human MAO A cDNAs

Monoamine Oxidases (MAOs) are integral proteins of the outer mitochondrial membrane. They are responsible for catalyzing the oxidative deamination of a wide variety of xenobiotic and endobiotic primary, secondary, and tertiary amines. Endobiotic substrates for these enzymes include catecholamine neurotransmitters: serotonin, dopamine, and norepinephine. Xenobiotic substrates include the serotonin receptor agonists Sumatriptan, Rizatriptan, and Zolmitriptan (anti-migraine drugs), and the neurotoxin MPTP. Many drugs currently on the market, and certain food products high in tyramine, are known to interact with MAOs producing harmful side effects.

MAO-A is found at high levels in the liver, gastrointestinal tract, and placenta and areas of the brain. This enzyme is particularly important in the catabolism of monoamines ingested in food.

Available size: 0.5 mL

Protein concentration: 5 mg/ mL

Product Number

456283

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Size

0.5 mL

Species

Human

Enzyme Type

MAO

Protein Concentration

5 mg/mL

Storage

-80 C

Cellular Location

Mitochondria