Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs

CYP2C8 is involved in the metabolism of several drug substrates such as the anti-cancer drug paclitaxel (TAXOL?), amodiaquine, torsemide, cervastatin, and repaglinide. Paclitaxel and amodiaquine are recommended probe substrates for CYP2C8. Endogenous CYP2C8 substrates include retinoic acid and arachidonic acid.

CYP2C8*3 is the major variant allele in Caucasian populations. The mutation results in significantly lower activity for certain CYP2C8 substrates relative to the wild-type enzyme (e.g., paclitaxel and arachadonic acid metabolism). In African-American populations the major allelic variant is CYP2C8*2. In Asian populations neither allelic variant is prevalent.

CYP2C8*3 and CYP2C9*2 allelic variants are linked (96% of 2C9*2/*2 are 2C8*3/*3 and 85% of 2C8*3/*3 are 2C9*2/*2).

Contains Human Oxidoreductase, but not cytochrome b?

Available size: 1.0 nmole P450 in 0.5 mL

Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.

Product Number

456212

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Size

1 nmol

Species

Human

Enzyme Type

P450

Protein Concentration

Lot-dependent

Storage

-80 C

Cellular Location

Microsome