Recombinant enzyme prepared from insect cells infected with baculovirus containing human MAO B cDNAs

Monoamine Oxidases (MAOs) are integral proteins of the outer mitochondrial membrane. They are responsible for catalyzing the oxidative deamination of a wide variety of xenobiotic and endobiotic primary, secondary, and tertiary amines. Endobiotic substrates for these enzymes include catecholamine neurotransmitters: serotonin, dopamine, and norepinephine. Xenobiotic substrates include the serotonin receptor agonists Sumatriptan, Rizatriptan, and Zolmitriptan (anti-migraine drugs), and the neurotoxin MPTP. Many drugs currently on the market, and certain food products high in tyramine, are known to interact with MAOs producing harmful side effects.

MAO-B is mostly found in blood platelets. Benzylamine and phenylethylamine are considered selective substrate for MAO B. Deprenyl has been shown to be a potent and selective inhibitor and is currently used in the treatment of Parkinson’s disease.

Available size: 0.5 mL

Protein concentration: 5 mg/ mL

Product Number

456284

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Size

0.5 mL

Species

Human

Enzyme Type

MAO

Protein Concentration

5 mg/mL

Storage

-80 C

Cellular Location

Mitochondria