Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs

CYP3A4 is on average the most abundant P450 in human liver. It is considered the most important P450 for drug metabolism, accounting for the metabolism of 50% or more of prescribed medications. CYP3A4 is also a major isoform in the intestine and can contribute significantly to oral first-pass metabolism of drugs.

CYP3A4 metabolizes cortisol, nifedipine, cyclosporin, testosterone, estrogen, ?-warfarin, gestodene, ketoconazole, miconazole, dapsone, FK-506, quinidine, lovastatin, erythromycin, and numerous other drugs. It is involved in many clinically important drug-drug interactions. CYP3A4 activates aflatoxin B?-related Carcinogens and senecionine. CYP3A4 protein levels can be induced several fold in the liver by ligands of CAR and PXR (e.g., phenobarbital, rifampin, and phenytoin).

Contains Human Oxidoreductase, but not cytochrome b?

Available size: 1.0 nmole P450 in 0.5 mL

Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.

Product Number

456207

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Size

1 nmol

Species

Human

Enzyme Type

P450

Protein Concentration

Lot-dependent

Storage

-80 C

Cellular Location

Microsome