Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs
CYP2C8 is involved in the metabolism of several drug substrates such as the anti-cancer drug paclitaxel (TAXOL?), amodiaquine, torsemide, cervastatin, and repaglinide. Paclitaxel and amodiaquine are recommended probe substrates for CYP2C8. Endogenous CYP2C8 substrates include retinoic acid and arachidonic acid.
CYP2C8*3 is the major variant allele in Caucasian populations. The mutation results in significantly lower activity for certain CYP2C8 substrates relative to the wild-type enzyme (e.g., paclitaxel and arachadonic acid metabolism). In African-American populations the major allelic variant is CYP2C8*2. In Asian populations neither allelic variant is prevalent. CYP2C8*3 and CYP2C9*2 allelic variants are linked (96% of 2C9*2/*2 are 2C8*3/*3 and 85% of 2C8*3/*3 are 2C9*2/*2).
Contains Human Oxidoreductase and cytochrome b?
Available size: 0.5 nmole P450 in 0.5 mL
Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.
Product Number
456252
Qty./Pk
1?/ Pk
Qty./Cs
1?/ Ea
Brand
Corning?
Size
0.5 nmol
Species
Human
Enzyme Type
P450
Protein Concentration
Lot-dependent
Storage
-80 C
Cellular Location
Microsome