Recombinant enzyme prepared from insect cells infected with baculovirus containing human UGT1A7 cDNAs

UDP-glucuronosyltransferases (UGT) represent the major phase II drug metabolism pathway in human. UGT enzymes catalyze the transfer of glucuronic acid (derived from UDPGA co-factor) to xenobiotics and endogenous substrates having nucleophilic acceptor groups, making them more polar and readily excreted in urine or bile. To date, at least 18 human UGT enzymes have been cloned and sequenced. Like the P450 enzymes, UGTs possess broad and overlapping substrate specificities. Clinically relevant drug interactions have been identified for UGT isoforms, leading regulatory agencies (FDA) to require drug interaction testing for compounds showing significant UGT metabolism.

UGT1A7 is an extra-hepatic UGT, not found in the liver, but in the intestinal tract, with highest levels in stomach. Compounds shown to be glucuronidated by UGT1A7 include 7-ethyl-10-hydroxycamptothecin (SN38) and mycophenolic acid.

Available size: 0.5 mL

Protein concentration: 5 mg/ mL

Product Number

456407

Qty./Pk

1?/ Pk

Qty./Cs

1?/ Ea

Brand

Corning?

Size

0.5 mL

Species

Human

Enzyme Type

UGT

Protein Concentration

5 mg/mL

Storage

-80 C

Cellular Location

Microsome