Kevetrin HCl
分子式: C5H10ClN3S分子量:179.67
简介: Kevetrin hydrochloride是水溶性的p53激活剂,具有潜在的抗肿瘤活性。
物理性状及指标:
外观:……………………粉末
溶解性:…………………H2O :36 mg/mL (200.37 mM);Ethanol:21 mg/mL (116.88 mM) ;DMSO: 36 mg/mL (200.37 mM)
含量:……………………>98%
储存温度:-20℃,避光防潮密闭干燥
生物活性
描述
|
Kevetrin盐酸盐是一种肿瘤抑制蛋白p53的激动剂, 具有潜在的抗肿瘤活性。 |
Description |
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target:p53 in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin’s development potential in this area. |
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储液配置及储存: 按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。
1 mg |
5 mg |
10 mg |
|
1 mM |
5.5658 mL |
27.8288 mL |
55.6576 mL |
5 mM |
1.1132 mL |
5.5658 mL |
11.1315 mL |
10 mM |
0.5566 mL |
2.7829 mL |
5.5658 mL |
50 mM |
0.1113 mL |
0.5566 mL |
1.1132 mL |
【注意 】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。
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