简介： Diclofenac 是一种有效的，非选择性的抗炎剂，为 COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 4 nM，1.3 nM；Diclofenac 同时对绵羊 COX-1 和 COX-2 的 IC50 值分别为 5.1 μM，0.84 μM。
中文名：双氯芬酸
物理性状及指标：
外观：……………………Almost white powder
溶解性：…………………Ethanol : ≥ 30mg/ml
含量：……………………≥99%,BR
储存温度：常温，避光防潮密闭干燥
生物活性（仅来自于公开文献）
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描述
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Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. |
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IC50 & Target |
Human COX-2 |
Human COX-1 |
Ovine COX-2 |
Ovine COX-1 |
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1.3 nM (IC50, in CHO cells) |
4 nM (IC50, in CHO cells) |
0.84 μM (IC50) |
5.1 μM (IC50) |
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体外 |
Diclofenac is a potent COX inhibitor, with IC50s of 4 nM and 1.3 nM for human COX-1 and COX-2 in the CHO cells, respectively. Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7 ± 3 nM. Diclofenac sodium exihibits inhibition on COX-1 and COX-2 enzyme with IC50s of 5.1 and 0.84 μM, respectively. |
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体内 |
Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. Diclofenac (10 mg/kg) shows anti-inflammatory activity in mice. Diclofenac (10 mg/kg) decreases oxidized low-densitylipoprotein (Ox-LDL), but shows no effects on the kinetics parameters of catalase and glutathione peroxidase via intramuscularly injection into rats. |
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储液配置及储存： 按表中溶解性配置；如溶解困难，可以通过快速搅拌，超声或温和加热（在45-55°C下水浴）。液体稳定性报道的很少，建议现配现用，如需储存，建议：-20℃1-3月；-80℃ 3-6月。
| 浓度/体积（乙醇）/质量 |
1 mg |
5 mg |
10 mg |
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1 mM |
3.3767 mL |
16.8833 mL |
33.7667 mL |
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5 mM |
0.6753 mL |
3.3767 mL |
6.7533 mL |
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10 mM |
0.3377 mL |
1.6883 mL |
3.3767 mL |
【注意】
●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。
我司所售出产品仅供于科研研究用途（非临床科研研究），每次销售产品行为都适用于我司网上所列明的。
质量标准：≥99%,BR
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TESTS |
SPECIFICATIONS |
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Appearance |
Almost white powder |
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Identification |
HNMR |
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Solubility |
30mg/ml Ethanol ,clear |
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Purity (HPLC) |
≥99% |