GF-109203X
分子式：C25H24N4O2 分子量：412.48
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产品描述 |
GF109203X是有效的PKC抑制剂，抑制PKCα, PKCβI, PKCβII,和PKCγ,IC50分别为20 nM, 17 nM, 16nM, 和 20 nM，作用于PKC比作用于EGFR, PDGFR和胰岛素受体选择性高3000倍以上。 |
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靶点 |
PKCα | PKCβI | PKCβII | PKCγ | ||
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IC50 |
20 nM | 17 nM | 16 nM | 20 nM | ||
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体外研究 |
GF109203X, as an ATP-competitive PKC inhibitor, prevents platelet aggregation induced by stimuli that activate PKC, and has the potential as a tool for studying the involvement of PKC in signal transduction pathways. [1] GF 109203X produces reversal activity on P-glycoprotein and MRP -mediated multidrug resistance. [2] [3] PKC inhibition by GF109203X significantly reduces carbachol-stimulated ERK1/2 activation and the subsequent proliferation of SNU-407 colon cancer cells. [ – See more at: http://www.selleckchem.com/products/gf109203x.html#sthash.sDMz4BKs.dpuf | |||||
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体内研究 |
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溶解性 |
DMSO 82 mg/mL，水 <1 mg/mL，乙醇 <1 mg/mL |
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稳定性 |
2年 -20°C粉状，6月-80°C溶于DMSO |
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特征 |
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运输条件：2~8℃运输
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CAS 号：133052-90-1
英文名字：Bisindolylmaleimide I (GF109203X)
质量标准：>98%,BR
分子式：C25H24N4O2
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