JBS Floppy-Choppy-MiTeGen用于难以结晶的蛋白质的救援套装
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JBS Floppy-Choppy
The JBS Floppy-Choppy is the rescue kit for proteins which are recalcitrant to crystallization. It enables the researcher to modify the protein target by in situ proteolysis to improve its crystallization behavior.
JBS Floppy-Choppy
JBS Floppy-Choppy 是用于难以结晶的蛋白质的救援套件。 它使研究人员能够通过原位蛋白水解来修饰蛋白质目标,以改善其结晶行为。
Product Information
- Product Description
- Product Specification
The JBS Floppy-Choppy is the rescue kit for proteins which are recalcitrant to crystallization. It enables the researcher to modify the protein target by in situ proteolysis to improve its crystallization behavior.The method implies the addition of trace amounts of protease to the protein solution immediately prior to crystallization. Thus, the crystallization experiment is very straightforward. It can be set up without evaluating the efficacy of proteolysis, without stopping the proteolysis reaction and without purification of any proteolyzed protein fragments
In situ proteolysis is one of the most efficacious crystallization rescue strategies used at structural genomic centers [1,2].
[1] Dong et al. (2007) In situ proteolysis for protein crystallization and structure determination.Nature Methods 4:1019.
[2] Wernimont et al. (2009) In situ Proteolysis to Generate Crystals for Structure Determination: An Update. PLoS ONE 4: e5094
JBS Floppy-Choppy, 1 kitFor additional questions please call +1 607 266 877 or email [email protected]