中文名:毒胡萝卜素 英文名:Thapsigargin, from Thapsia garganica
分子式:C34H50O12 分子量:650.75
质量标准: >97% (HPLC),进分
熔点:84-90°C
外观:白色至类白色固体
溶解性及工作液制备:soluble in DMSO and ethanol .
TG is soluble in DMSO and in ethanol. No initial concentrations of TG were given for either solvent but it was noted that the final concentrations were:
in DMSO,less than 1% (v/v); ethanol, did not exceed 1% of the total volume (working concentrations in ethanol were from 70-140 mM). Neither amount of solvent
had any adverse effects in the described systems. Preparation of a 3% (w/v) solution in deuterated DMSO was described.
TG has been solubilized in acetonitrile at 10 mg/ml producing a clear,colorless solution. TG is also soluble in methanol,diethyl ether, and methylene chloride.
Solutions are recommended to be prepared fresh. However, if necessary, solutions can be stored at –20 °C under argon or nitrogen.
A 1 mM solution in DMSO was reportedly stored at –20 °C (no storage time given).
生物活性:Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin.
Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations
包装规格:1MG/只;
储存条件:-20℃,避光防潮密闭干燥。
运输条件:2~8℃运输
用途:用于分析含量鉴定/测定,药理活性筛选;仅供科研严禁用于人体
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CAS 号:67526-95-8
英文名字:毒胡萝卜素
质量标准:>97% (HPLC),进分
分子式:C34H50O12
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